Phenotypes Associated with This Genotype

Genotype
MGI:5646171

• Allelic Composition: Tg(Thy1-APPSw)10Jiri/0; Tg(Thy1-PSEN1*M146V)#Jiri/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:91273 )

• in the object recognition test, mice exhibit lower recognition indices than wild-type mice at 6, 8, and 10 months of age, but not at 3 or 4 months of age

homeostasis/metabolism

amyloid beta deposits ( J:91273 , J:222897 )

• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)

• amyloid beta load is greater in females than males (J:91273)

• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)

• amyloid beta deposits are seen in the cerebrovasculature (J:91273)

• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)

nervous system

amyloid beta deposits ( J:91273 , J:222897 )

• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)

• amyloid beta load is greater in females than males (J:91273)

• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)

• amyloid beta deposits are seen in the cerebrovasculature (J:91273)

• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)

abnormal neurite morphology ( J:91273 )

• cortical plaques are surrounded by clusters of dystrophic neurites

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:222897