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Phenotypes Associated with This Genotype
Genotype
MGI:5644542
Allelic
Composition
Atmtm1Pmc/Atmtm1Pmc
Genetic
Background
B6.Cg-Atmtm1Pmc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Pmc mutation (0 available); any Atm mutation (125 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit glucose intolerance
• rosiglitazone treatment or metformin treatment improve glucose intolerance in mutants
• reduction in serum adiponectin levels
• rosiglitazone, but not metformin, treatment increases serum adiponectin levels in mutants

adipose tissue
• decrease in the amount of intrascapular and subcutaneous fat tissue and an increase in the amount of visceral fat tissue
• mouse embryonic fibroblasts (MEFs) fail to differentiate into adipocytes in vitro
• rosiglitazone treatment restores adipocyte differentiation in MEFs

behavior/neurological

cellular
• mouse embryonic fibroblasts (MEFs) fail to differentiate into adipocytes in vitro
• rosiglitazone treatment restores adipocyte differentiation in MEFs
• MEFs re-enter the cell cycle normally after differentiation stimulation, but the cell cycle is not arrested at 8 days after differentiation stimulation as seen in wild-type MEFs undergoing terminal differentiation

integument

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ataxia telangiectasia DOID:12704 OMIM:208900
J:222034


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory