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Phenotypes Associated with This Genotype
Genotype
MGI:5644519
Allelic
Composition		 \Igh-Jtm1Aigl/\Igh-Jtm1Aigl
\Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Aigl mutation (0 available); any Igh-J mutation (13 available)
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ig deposition and B cell infiltrates in spinal cord of sick Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0 Igh-Jtm1Aigl/Igh-Jtm1Aigl and Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0 mice

immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:149511 )
• mice develop spontaneous experimental autoimmune encephalomyelitis (EAE) at high frequency
• almost all females develop EAE by 120 days of age, while fewer than 40% develop EAE by this time
increased autoantibody level ( J:149511 )
• mice produce anti-MOG autoantibodies, dominated by the transgene specific allotype Igha

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory