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Phenotypes Associated with This Genotype
Genotype
MGI:5643692
Allelic
Composition		 Rspo3tm1Arte/Rspo3tm1Arte
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (0 available); any Isl1 mutation (38 available)
Rspo3tm1Arte mutation (0 available); any Rspo3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:214093 )
• late gestational lethality at E14.5-E16.5 in most mice due to cardiovascular failure

cardiovascular system
double outlet right ventricle ( J:214093 )
• all mice exhibit small right ventricle and/or double outlet right ventricle
decreased heart right ventricle size ( J:214093 )
• all mice exhibit small right ventricle and/or double outlet right ventricle

homeostasis/metabolism

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory