About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5641710
Allelic
Composition
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (52 available)
Tsc2tm1.1Mjg mutation (1 available); any Tsc2 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• most females that reach 31 weeks of age or older exhibit myometrial tumors in the lungs, suggesting lymphangioleiomyomatosis

muscle
• mice exhibit myometrial overgrowth, developing tumors consistent with leiomyomas by 24 weeks of age

reproductive system
• mice exhibit myometrial overgrowth, developing tumors consistent with leiomyomas by 24 weeks of age
• increase in endometrial proliferation, with more endometrial glands and irregular luminal epithelium in uteri
• increase in myometrial proliferation at 12 weeks of age
• myometrium is thickened with rough borders and irregular, disoriented cells
• ovariectomy in 4 week old mice prevents abnormal uterine growth and estrogen stimulates myometrial proliferation in ovariectomized females
• treatment with aromatase inhibitor, letrozole, for 8 weeks starting at 4 weeks of age, reduces myometrial proliferation
• starting at 6 weeks of age, mice start to show uterine enlargement, and uterine size and weight are larger at 12 weeks of age
• treatment with rapamycin at 4 weeks of age for 8 weeks completely prevents abnormal growth in the uterus
• at 12 weeks of age

neoplasm
• mice exhibit myometrial overgrowth, developing tumors consistent with leiomyomas by 24 weeks of age
• tumors in the lungs originate from the lymphatics, suggesting that lung tumors are metastatic from the uterus
• most females that reach 31 weeks of age or older exhibit myometrial tumors in the lungs, suggesting lymphangioleiomyomatosis

cardiovascular system
• 24 week old mice show appreciably larger uteri, with continued endometrial overgrowth and internal bleeding

endocrine/exocrine glands

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
uterine fibroid DOID:13223 OMIM:150699
J:221228


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory