Phenotypes Associated with This Genotype

Genotype
MGI:5638676

• Allelic Composition: App^tm2.1Tcs/App^tm2.1Tcs; Cast^tm1Tcs/Cast^tm1Tcs
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:212758 )

• mice exhibit an increase in memory impairment in the Y-maze test by 3 months compared to single APP^tm2.1Tcs homozygotes

hematopoietic system

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes

homeostasis/metabolism

amyloidosis ( J:212758 )

• amyloid beta amyloidosis is exacerbated compared to single APP^tm2.1Tcs homozygotes

amyloid beta deposits ( J:212758 )

immune system

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes

nervous system

astrocytosis ( J:212758 )

• astrocytosis is increased compared to single APP^tm2.1Tcs homozygotes

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes

amyloid beta deposits ( J:212758 )

cellular

astrocytosis ( J:212758 )

• astrocytosis is increased compared to single APP^tm2.1Tcs homozygotes

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes