Phenotypes for Apc Msh2 Nos2 MGI:5636667 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc⁺ Msh2^tm1Mak/Msh2⁺ Nos2^tm1Mrl/Nos2^tm1Mrl
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (151 available)
Msh2^tm1Mak mutation (1 available); any Msh2 mutation (95 available)
Nos2^tm1Mrl mutation (6 available); any Nos2 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:200824 )

• mutants exhibit enhanced polyp number in the small intestine, but not in the colon compared to double Apc^Min Msh2^tm1Mak heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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