Phenotypes for H2 Rag1 Tg(HLA-DRA,HLA-DRB5*0101)loKito Tg(TRATL3A6,TRBTL3A6)#Kito MGI:5635503 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (15 available); any H2 mutation (304 available)
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (132 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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