Phenotypes Associated with This Genotype

Genotype
MGI:5635488

• Allelic Composition: H2^dlAb1-Ea/H2^dlAb1-Ea; Tg(HLA-DRA,HLA-DRB5*0101)loKito/0; Tg(TRATL3A6,TRBTL3A6)#Kito/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:189816 )

• mice rarely exhibit experimental autoimmune encephalitis when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 47% of mice

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age