Phenotypes Associated with This Genotype

Genotype
MGI:5634792

• Allelic Composition: Cacna1a^tg/Cacna1a^tg
• Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:262 )

• mutant mice occasionally fall over

impaired limb coordination ( J:262 )

• toeing-out of hind feet is often noticeable before the gait becomes abnormal

• mutant mice often lean to one side

impaired swimming ( J:262 )

abnormal posture ( J:262 )

• the bodies of mutant mice are held closer to the ground

abnormal gait ( J:262 )

• Background Sensitivity: mutant mice are recognizeable by 2.5 weeks of age

abnormal maternal nurturing ( J:262 )

• due to effects of seizures

seizures ( J:262 )

• a seizure pattern develops in mutant mice by 3 weeks of age

• preceded by increased running with abrupt directional changes followed by no motor activity and increased respiration

• begin as early as 2 weeks of age as sporadic seizures

• have little effect on life span

sporadic seizures ( J:262 )

• begin as early as 2 weeks of age

• preceded by flattening of the sacral area with spastic abduction and extension of a hind limb

nervous system

seizures ( J:262 )

• a seizure pattern develops in mutant mice by 3 weeks of age

• preceded by increased running with abrupt directional changes followed by no motor activity and increased respiration

• begin as early as 2 weeks of age as sporadic seizures

• have little effect on life span

sporadic seizures ( J:262 )

• begin as early as 2 weeks of age

• preceded by flattening of the sacral area with spastic abduction and extension of a hind limb

reproductive system

reduced fertility ( J:262 )

• in both sexes due to impact of the neurological phenotype