Phenotypes Associated with This Genotype

Genotype
MGI:5632201

• Allelic Composition: Lrp5^tm1Grw/Lrp5^tm1Grw; Sost^tm1Paz/Sost^tm1Paz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral content ( J:213541 )

• mice exhibit bone mineral content that is greater than in single Lrp5 homozygotes and intermediate between those of wild-type and single Sost homozygotes

increased bone mineral density ( J:213541 )

• mice exhibit whole-body mineral density that is greater than in single Lrp5 homozygotes and intermediate between those of wild-type and single Sost homozygotes

• however, mineral apposition rates and bone formation rates do not differ from wild-type mice but are increased compared to single Lrp5 homozygotes

increased bone volume ( J:213541 )

• mice exhibit bone volume fraction (BV/TV) values that are greater than in single Lrp5 homozygotes and are intermediate between those of wild-type and single Sost homozygotes

• females exhibit a greater increase in BV/TV than male mice

increased bone trabecula number ( J:213541 )

• females exhibit a greater increase in trabecular number than male mice

increased bone mass ( J:213541 )

increased compact bone mass ( J:213541 )

increased trabecular bone mass ( J:213541 )

increased bone stiffness ( J:213541 )

• increase in bone stiffness compared to wild-type mice and single Lrp5 homozygotes

increased bone strength ( J:213541 )

• bones show increased ultimate force, energy to failure, and stiffness, indicating enhanced bone strength compared to wild-type mice and single Lrp5 homozygotes