Phenotypes Associated with This Genotype

Genotype
MGI:5630865

• Allelic Composition: Arpc1b^{tm1a(EUCOMM)Wtsi}/Arpc1b^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Arpc1b^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0423_1_B04

Data Sources

IMPC Data for Arpc1b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body length ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - WTSI

increased red blood cell distribution width ( J:211773 )

♀

IMPC - WTSI

thrombocytosis ( J:211773 )

♀

IMPC - WTSI

increased mean platelet volume ( J:211773 )

IMPC - WTSI

increased CD103-positive CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased marginal zone precursor B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased mature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

♀

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased macrophage cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

increased immature NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♀

IMPC - WTSI

increased circulating calcium level ( J:211773 )

♂

IMPC - WTSI

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

IMPC - WTSI

increased circulating total protein level ( J:211773 )

IMPC - WTSI

immune system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

increased CD103-positive CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased marginal zone precursor B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased mature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

♀

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased macrophage cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

increased immature NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

integument

pigment incontinence ( J:232539 )

♀ • at necropsy (15.9 weeks of age), mice show mild to moderate multifocal areas of dermal fibrosis with pigment laden macrophages suggesting hair follicle rupture

skin fibrosis ( J:232539 )

♀ • mild to moderate multifocal areas of dermal fibrosis

pigmentation

pigment incontinence ( J:232539 )

♀ • at necropsy (15.9 weeks of age), mice show mild to moderate multifocal areas of dermal fibrosis with pigment laden macrophages suggesting hair follicle rupture

skeleton

vertebral fusion ( J:211773 )

♂

IMPC - WTSI

fusion of vertebral arches ( J:211773 )

♂

IMPC - WTSI