Phenotypes Associated with This Genotype

Genotype
MGI:5629847

• Allelic Composition: lgl/lgl
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:9298 )

• may not develop

ectrodactyly ( J:9298 )

• of preaxial digits

abnormal forelimb morphology ( J:9298 )

• mutant mice lack any number of digits and the radius and carpus may be rudimentary or missing

abnormal radius morphology ( J:9298 )

• missing or rudimentary in some mutant mice

abnormal hindlimb morphology ( J:9298 )

• 90% of mutant mice appear legless because only the femur develops

nervous system

abnormal embryonic neuroepithelium morphology ( J:9298 )

• cell disorganization and necrosis of the anterior aspect is commonly seen in 20-somite embryo

abnormal brain development ( J:9298 )

• abnormal brain shape is common in newborns

hydrocephaly ( J:9298 )

• involves the lateral ventricles of the brain of many newborns

abnormal cerebral hemisphere morphology ( J:9298 )

• anterior structures are abnormal and distinctive hemispheric shape is absent

abnormal cerebral cortex morphology ( J:9298 )

• 46% of mutant mice have hemorrhagic protrusions from the cerebral cortex, seen externally as "bumps" between the eyes

abnormal olfactory lobe morphology ( J:9298 )

• abnormal or missing lobes are common

craniofacial

abnormal craniofacial morphology ( J:9298 )

• 40% of mutant mice have cleft lip and/or cleft palate

cleft upper lip ( J:9298 )

abnormal palate morphology ( J:9298 )

cleft palate ( J:9298 )

thin nasal septum ( J:9298 )

• thinning of the nasal septum is commonly seen in newborns

facial cleft ( J:9298 )

growth/size/body

cleft upper lip ( J:9298 )

abnormal palate morphology ( J:9298 )

cleft palate ( J:9298 )

thin nasal septum ( J:9298 )

• thinning of the nasal septum is commonly seen in newborns

facial cleft ( J:9298 )

skeleton

abnormal carpal bone morphology ( J:9298 )

• may not develop

abnormal radius morphology ( J:9298 )

• missing or rudimentary in some mutant mice

digestive/alimentary system

abnormal palate morphology ( J:9298 )

cleft palate ( J:9298 )

respiratory system

thin nasal septum ( J:9298 )

• thinning of the nasal septum is commonly seen in newborns

embryo

abnormal embryonic neuroepithelium morphology ( J:9298 )

• cell disorganization and necrosis of the anterior aspect is commonly seen in 20-somite embryo

mortality/aging

neonatal lethality, complete penetrance ( J:9298 )