Phenotypes Associated with This Genotype

Genotype
MGI:5614487

• Allelic Composition: Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺; Cd19^{tm1(cre/ERT2)Rsky}/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:217520 )

• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

increased B cell number ( J:217520 )

• CD19+ B cells in tamoxifen-treated mice

• B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

• however, cell counts return to baseline after 2 weeks and a second application of tamoxifen does not result in another wave of B cell expansion

increased CD4-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased CD8-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased activated T cell number ( J:217520 )

• in tamoxifen-treated mice

• however, T cell numbers decrease 8 days after tamoxifen application

abnormal T cell physiology ( J:217520 )

• vigorous degranulation when T cells from tamoxifen-treated mice are exposed to LMP1-transduced B cells in vitro

hematopoietic system

enlarged spleen ( J:217520 )

• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

increased B cell number ( J:217520 )

• CD19+ B cells in tamoxifen-treated mice

• B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

• however, cell counts return to baseline after 2 weeks and a second application of tamoxifen does not result in another wave of B cell expansion

increased CD4-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased CD8-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased activated T cell number ( J:217520 )

• in tamoxifen-treated mice

• however, T cell numbers decrease 8 days after tamoxifen application

abnormal T cell physiology ( J:217520 )

• vigorous degranulation when T cells from tamoxifen-treated mice are exposed to LMP1-transduced B cells in vitro

growth/size/body

enlarged spleen ( J:217520 )

• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice