Phenotypes Associated with This Genotype

Genotype
MGI:5614433

• Allelic Composition: Epha4^tm1.1Bzh/Epha4^tm1.2Bzh; Tg(Slc17a6-icre)1Oki/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:209606 )

• quadrupedal hopping gait is dominant at all locomotor frequencies

• occasional alternating gait is seen at lower frequencies

nervous system

abnormal corticospinal tract morphology ( J:209606 )

• increase in axon midline crossing

abnormal spinal cord morphology ( J:209606 )

• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus

abnormal spinal cord dorsal column morphology ( J:209606 )

• wider and the distance from the ventral edge to the surface of the spinal cord is shorter; however, the total area is not different from controls

abnormal nerve fiber response ( J:209606 )

• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity