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Phenotypes Associated with This Genotype
Genotype
MGI:5613181
Allelic
Composition		 LynM2Btlr/Lyn+
Genetic
Background		 C57BL/6J-LynM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LynM2Btlr mutation (0 available); any Lyn mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgG level ( J:217146 )
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
decreased IgM level ( J:217146 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

immune system
decreased IgG level ( J:217146 )
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
decreased IgM level ( J:217146 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:217146 )
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory