Phenotypes for Mc4r Slc17a6 MGI:5609677 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mc4r^tm1Lowl/Mc4r^tm1Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm1Lowl mutation (2 available); any Mc4r mutation (46 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:216397 )

N	• rescue of the increased weight gain, of the fat stores, of hyperphagia and of the increased linear length seen in single Mc4r homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:216397 )

N	• mice show normalization of the hyperglycemia and hyperinsulinemia that is seen in single Mc4r homozygotes

respiratory system

respiratory system phenotype ( J:216397 )

N	• rescue of the depressed respiratory exchange ratio seen in single Mc4r homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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