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Phenotypes Associated with This Genotype
Genotype
MGI:5607935
Allelic
Composition		 Semg1tm1Kemi/Semg1tm1Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm1Kemi mutation (1 available); any Semg1 mutation (30 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Membrane disruption of intrauterine sperm in Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0

reproductive system
abnormal sperm physiology ( J:207389 )
• intrauterine death of sperm
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
premature acrosome reaction ( J:207389 )
• ejaculated sperm have already undergone the acrosomal reaction inside the uterus

cellular
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory