Phenotypes Associated with This Genotype

Genotype
MGI:5607632

• Allelic Composition: Abcg5^tm1.1Hobb/Abcg5^tm1.1Hobb; Abcg8^tm1.1Hobb/Abcg8^tm1.1Hobb; Tg(Vil1-cre)997Gum/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular cholesterol metabolism ( J:215443 )

digestive/alimentary system

abnormal feces composition ( J:215443 )

increased intestinal phytosterol absorption ( J:215443 )

• rate of clearance of sitosterol from circulation is decreased

• fractional absorption of the phytosterol, campesterol, is increased

homeostasis/metabolism

abnormal cellular cholesterol metabolism ( J:215443 )

increased intestinal phytosterol absorption ( J:215443 )

• rate of clearance of sitosterol from circulation is decreased

• fractional absorption of the phytosterol, campesterol, is increased

increased phytosterol level ( J:215443 )

♀ • increased levels of phytosterols in enterocytes

♀ • increased levels of biliary plant sterols (sitosterol and campesterol) as compared to controls

increased circulating phytosterol level ( J:215443 )

♀ • mean plasma levels of sitosterol and campesterol are increased as compared to controls, but are not as high as mice that carry null alleles for both Abcg5 and Abcg8

decreased cholesterol efflux ( J:215443 )

• decreased amount of cholesterol is excreted into the feces as compared to controls