Phenotypes Associated with This Genotype

Genotype
MGI:5607618

• Allelic Composition: Abcg5^tm1.1Hobb/Abcg5^tm1.1Hobb; Abcg8^tm1.1Hobb/Abcg8^tm1.1Hobb; Speer6-ps1^{Tg(Alb-cre)21Mgn}/?
• Genetic Background: involves: C57BL/6 * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal feces composition ( J:215443 )

abnormal intestinal cholesterol absorption ( J:215443 )

• rate of clearance of sitosterol from circulation is decreased

homeostasis/metabolism

abnormal cellular cholesterol metabolism ( J:215443 )

• rate of clearance of sitosterol from circulation is decreased

abnormal intestinal cholesterol absorption ( J:215443 )

• rate of clearance of sitosterol from circulation is decreased

decreased circulating cholesterol level ( J:215443 )

♀ • decreased levels of circulating cholesterol as compared to controls

increased cholesterol level ( J:215443 )

♀ • levels of cholesterol in the liver are increased as compared to controls

♀ • levels of biliary cholesterol are increased as compared to controls

abnormal phytosterol level ( J:215443 )

increased circulating phytosterol level ( J:215443 )

♀ • mean plasma levels of sitosterol and campesterol are increased as compared to controls, but are not as high as mice that carry null alleles for both Abcg5 and Abcg8

decreased phytosterol level ( J:215443 )

♀ • levels of sitosterol and campesterol are decreased in gallbladder as compared to controls

♀ • levels of the plant sterol, stigmasterol, are decreased 6X in the liver as compared to mice that carry null alleles for both Abcg5 and Abcg8

decreased cholesterol efflux ( J:215443 )

♂ • decreased amount of cholesterol is excreted into the feces as compared to controls

♂ • decreased amount of cholesterol is excreted into the bile as compared to controls

cellular

abnormal cellular cholesterol metabolism ( J:215443 )

• rate of clearance of sitosterol from circulation is decreased