Phenotypes Associated with This Genotype

Genotype
MGI:5605991

• Allelic Composition: Wnt5a^tm1Amc/Wnt5a^tm1.1Krvl; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:196291 )

• pups die within a few hours of birth

nervous system

increased neuron apoptosis ( J:196291 )

• increased neuron apoptosis observed in superior cervical ganglia

abnormal axon extension ( J:196291 )

• defects in extension and branching of sympathetic axons are observed in salivary glands, thymus, heart, spleen and bladder at E16.5

abnormal sympathetic neuron innervation pattern ( J:196291 )

• incomplete innervation in paravertebral sympathetic ganglia and prevertebral ganglia

• sympathetic axons in spleen extend to target, but fail to grow and arborize spleen parenchyma

craniofacial

abnormal craniofacial morphology ( J:196291 )

• pups exhibit craniofacial abnormalities

cellular

increased neuron apoptosis ( J:196291 )

• increased neuron apoptosis observed in superior cervical ganglia

abnormal axon extension ( J:196291 )

• defects in extension and branching of sympathetic axons are observed in salivary glands, thymus, heart, spleen and bladder at E16.5