Phenotypes Associated with This Genotype

Genotype
MGI:5605670

• Allelic Composition: Atrn^mg-3J/Atrn⁺; Pepd^dal/Pepd^dal
• Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

darkened coat color ( J:143333 )

• mice homozygous for dark-like and heterozgyous for the mahogany 3 Jackson allele of attractin have a darker coat color than mice homozygous for dark-like and wildtype for attractin

pigmentation

darkened coat color ( J:143333 )

• mice homozygous for dark-like and heterozgyous for the mahogany 3 Jackson allele of attractin have a darker coat color than mice homozygous for dark-like and wildtype for attractin

endocrine/exocrine glands

abnormal testis morphology ( J:143333 )

♂ • at 3 months of age 13 out of 17 mice homozygous for dark-like on this background display significant vacuolation in the testes regardless of whether they are heterozgyous or wild-type for the mahogany 3 Jackson allele, and at 6 months of age this is increased to 9 out of 10 assessed

reproductive system

abnormal testis morphology ( J:143333 )

♂ • at 3 months of age 13 out of 17 mice homozygous for dark-like on this background display significant vacuolation in the testes regardless of whether they are heterozgyous or wild-type for the mahogany 3 Jackson allele, and at 6 months of age this is increased to 9 out of 10 assessed

nervous system

brain vacuoles ( J:143333 )

• at 2-3 months of age no vacuoles are found in compound heterozgyotes, 2 of 5 dark-like homozygotes wild-type for attractin have vacuolation in multiple brain regions, while dark-like homozygotes heterozygous for mahogany 3 Jackson have a range of CNS vacuolation from undetectable to severe