Phenotypes Associated with This Genotype

Genotype
MGI:5605192

• Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv}; Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv}; Il2rg^tm1.1Flv/Il2rg^tm1.1Flv; Rag2^tm1.1Flv/Rag2^tm1.1Flv; Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}
• Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal response to transplant ( J:207289 )

• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/Sz J controls

• peripheral blood is mostly composed of human monocytes

• bone marrow is composed of human monocytes and neutrophils

• numbers of myeloid cells in non lymphoid tissues (lung, liver, colon) are incerased by 10 fold that of controls

• numbers of human NK cells found in blood and liver are higher in engrafted mutant as compared to controls, however, numbers are not as high as in mice that also carry Tg(SIRPA)1Flv

• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls

• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls