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Phenotypes Associated with This Genotype
Genotype
MGI:5604879
Allelic
Composition
Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe/?
Tg(Pdx1-cre)6Tuv/?
Genetic
Background
B6.Cg-Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe Tg(Pdx1-cre)6Tuv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Pdx1-cre)6Tuv mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• beta cells, identified by immunostaining for insulin, occupied a greater proportional area of pancreas sections from adult mice bearing both the conditional Neurog3 knock-in and the embryonically expressed (E9.5-E12.5) pancreatic progenitor cell-specific cre recombinase transgene than in sections from control mice with only the conditional allele (highly significant at p = 0.007 (<= 0.01) by Student's unpaired t test).


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory