Phenotypes Associated with This Genotype

Genotype
MGI:5604751

• Allelic Composition: Tg(CAG-Bgeo,-tsA58T)T26Ichi/0; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:214846 )

• mice die within 200 days after birth, showing symptoms to that seen in wasting disease

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:214846 )

• mice develop pancreatic acinar cell dysplasia by 22 weeks without PanIN formation

abnormal pancreatic duct morphology ( J:214846 )

• pancreatic ductal system and ductal cells are atrophic by 22 weeks of age

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:214846 )

• mice develop pancreatic acinar cell dysplasia by 22 weeks without PanIN formation

abnormal pancreatic duct morphology ( J:214846 )

• pancreatic ductal system and ductal cells are atrophic by 22 weeks of age