Phenotypes Associated with This Genotype

Genotype
MGI:5604449

• Allelic Composition: Tg(Mdm2)1Snj/0; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lymphoma incidence ( J:51661 )

• 67% of mice develop lymphoma

• 14 of 26 tumors are malignant lymphoma

increased medulloblastoma incidence ( J:51661 )

• 1 of 16 tumors is a medulloblastoma

increased squamous cell carcinoma incidence ( J:51661 )

• 1 of 16 tumors is a squamous cell carcinoma

increased hemangiosarcoma incidence ( J:51661 )

• 8 of 26 tumors are hemangiosarcomas

increased osteosarcoma incidence ( J:51661 )

• 2 of 16 tumors are osteosarcomas

skeleton

increased osteosarcoma incidence ( J:51661 )

• 2 of 16 tumors are osteosarcomas

nervous system

increased medulloblastoma incidence ( J:51661 )

• 1 of 16 tumors is a medulloblastoma