Phenotypes Associated with This Genotype

Genotype
MGI:5604244

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-Aimp1)29872Mcla/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased lung endothelial cell apoptosis ( J:173904 )

• 3 fold increase in caspase 3 activity in lung alveolar cells is measured as early as 4 weeks after doxycycline (dox) induction

hematopoietic system

increased macrophage cell number ( J:173904 )

• 28 weeks of doxycycline induction results in an increase in the number of alveolar macrophages in bronchoalveolar lavage fluid (BALF) and lung parenchyma from lung lysates

immune system

increased macrophage cell number ( J:173904 )

• 28 weeks of doxycycline induction results in an increase in the number of alveolar macrophages in bronchoalveolar lavage fluid (BALF) and lung parenchyma from lung lysates

respiratory system

increased lung endothelial cell apoptosis ( J:173904 )

• 3 fold increase in caspase 3 activity in lung alveolar cells is measured as early as 4 weeks after doxycycline (dox) induction

abnormal pulmonary acinus morphology ( J:173904 )

• increase in diameters of acinar airspaces (comprising alveolar ducts and alveoli) following dox treatment as compared to controls

dilated pulmonary alveolar duct ( J:173904 )

• following doxycycline induction

overexpanded pulmonary alveolus ( J:173904 )

• following doxycycline induction

emphysema ( J:173904 )

• following doxycycline induction