Phenotypes Associated with This Genotype

Genotype
MGI:5588820

• Allelic Composition: Tshz1^tm1Garr/Tshz1^tm2.1Garr; Tg(Nes-cre)1Kln/?
• Genetic Background: involves: 129S1/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:209428 )

• approx. 70% died during the first four postnatal weeks

• mutant mice could suckle and survive during the early postnatal period

growth/size/body

postnatal growth retardation ( J:209428 )

• mutants weighed around half that of their littermates

nervous system

abnormal olfactory bulb development ( J:209428 )

• a substantial reduction in the number of GABAergic cells

abnormal rostral migratory stream morphology ( J:209428 )

abnormal olfactory bulb periglomerular cell morphology ( J:209428 )

abnormal olfactory bulb granule cell layer morphology ( J:209428 )

small olfactory bulb ( J:209428 )

behavior/neurological

abnormal olfactory discrimination memory ( J:209428 )