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Phenotypes Associated with This Genotype
Genotype
MGI:5588383
Allelic
Composition
Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Grem1)Svok mutation (1 available); any Gt(ROSA)26Sor mutation (1062 available)
Shhtm1(EGFP/cre)Cjt mutation (2 available); any Shh mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• hindlimbs from some E18.5 embryos have multiple posterior distal bifurcations (1/4)
• forelimbs from some E18.5 embryos have large nubs in the posterior (3/4)
• hindlimbs from some E18.5 embryos have posterior polydactyly (3/4)
• forelimbs from some E18.5 embryos have preaxial polydactyly (1/4)

skeleton
• hindlimbs from some E18.5 embryos have multiple posterior distal bifurcations (1/4)
• forelimbs from some E18.5 embryos have large nubs in the posterior (3/4)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory