Phenotypes Associated with This Genotype

Genotype
MGI:5588205

• Allelic Composition: Hsbp1^tm1Miv/Hsbp1^tm1Miv
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:206878 )

• complete lethality at the preimplantation stage

• 57.7% of embryos are arrested or degenerated before reaching the blastocyst stage and only 3.8% of the blastocysts hatch

embryo

abnormal endoderm development ( J:206878 )

• embryoid bodies show disorganization of the germ layers and a reduction in the endoderm-specific markers and an increase in the expression of neural crest inducers

• however, embryonic stem cells survive and proliferate normally into the neural lineage in vitro