Phenotypes Associated with This Genotype

Genotype
MGI:5588163

• Allelic Composition: Erbb3^tm3Cbm/Erbb3^tm3Cbm; Gt(ROSA)26Sor^{tm8(Map2k1*,-EGFP)Rsky}/?; Tg(Dhh-cre)1Mejr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased myelin sheath thickness ( J:207470 )

• at P15, the myelin of peripheral axons is thinner but axons are hypermyelinated at P90

abnormal myelination ( J:207470 )

• at P15 and P90, 36.7% and 17.8% of axons with diameters >1 um are nonmyelinated, respectively compared to 3.5% and 0.8% in controls

hypermyelination ( J:207470 )

• axons are hypermyelinated at P90

• however, mice show rescue of Schwann cell development and Schwan cells are able to myelinate