Phenotypes Associated with This Genotype

Genotype
MGI:5586709

• Allelic Composition: Crb2^tm1.1Wij/Crb2^tm1.1Wij; Tg(Pdgfra-cre)1Clc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:210675 )

• mice are born at a 5-fold reduced ratio than expected

vision/eye

abnormal retina layer morphology ( J:210675 )

• protrusion of photoreceptor nuclei into the subretinal space at sites of outer limiting membrane disruption at 5 months of age

• however, 5 month old mice show normal electroretinography (ERG), scanning laser ophthalmoscopy, and spectral domain optical coherence tomography readings

abnormal retina outer nuclear layer morphology ( J:210675 )

• ectopic Muller glial cell nuclei in the outer nuclear layer and activated Muller glial cells are seen at 5 months of age

thin retina outer nuclear layer ( J:210675 )

• at 5 months of age, a reduction of the outer nuclear layer thickness is seen

abnormal retina outer limiting membrane morphology ( J:210675 )

• disruptions of the outer limiting membrane at the periphery of the retina, where rows of photoreceptor nuclei protrude into the subretinal space, are seen at 1, 3, and 5 months of age