Phenotypes Associated with This Genotype

Genotype
MGI:5585456

• Allelic Composition: Mir22^tm1.2Dzw/Mir22^tm1.2Dzw; Tg(Myh6-Ppp3ca)37Eno/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:213308 )

• dramatic cardiac hypertrophy as indicated by an increase in heart weight to body weight ratio at 1 month of age that is similar to single Tg(Myh6-Ppp3ca)37Eno mice

abnormal heart ventricle wall thickness ( J:213308 )

• thickening of the left ventricle free wall and septum are decreased compared to single Tg(Myh6-Ppp3ca)37Eno mice

cardiac fibrosis ( J:213308 )

• mice show an increase in cardiac fibrosis compared to single Tg(Myh6-Ppp3ca)37Eno mice

growth/size/body

cardiac hypertrophy ( J:213308 )

• dramatic cardiac hypertrophy as indicated by an increase in heart weight to body weight ratio at 1 month of age that is similar to single Tg(Myh6-Ppp3ca)37Eno mice