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Phenotypes Associated with This Genotype
Genotype
MGI:5581815
Allelic
Composition		 Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas
Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gck)Ydor mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Pdx1-cre/Esr1*)#Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell physiology ( J:210493 )
• beta cells from tamoxifen-treated mice exhibit signs of DNA damage and apoptosis compared to control mice but to a lesser extent than in mice lacking Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas

homeostasis/metabolism
hyperglycemia ( J:210493 )
• severe in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory