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Phenotypes Associated with This Genotype
Genotype
MGI:5581665
Allelic
Composition		 Apptm1Ck/Apptm1Ck
Tg(PDGFB-PSEN1)1Jhd/0
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Ck mutation (0 available); any App mutation (111 available)
Tg(PDGFB-PSEN1)1Jhd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:102542 )
• areas of higher density of cholinergic fibers in the cortex at 20 months of age
• however, mice do not form amyloid beta plaques

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory