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Phenotypes Associated with This Genotype
Genotype
MGI:5581645
Allelic
Composition		 Apptm1Ck/Apptm1Ck
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Ck mutation (0 available); any App mutation (118 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased anxiety-related response ( J:191170 )
• in the elevated plus maze, mice show decreased open time and increased closed time

nervous system
abnormal brain morphology ( J:191170 )
• corticotropin releasing factor levels are increased in the lateral dorsal bed nucleus of the stria terminalis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory