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Phenotypes Associated with This Genotype
Genotype
MGI:5578652
Allelic
Composition		 Ergtm1.1Sho/Ergtm1.1Sho
Ptentm1Hwu/Ptentm1Hwu
Tmprss2tm3Sho/Tmprss2tm3Sho
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergtm1.1Sho mutation (0 available); any Erg mutation (27 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
Tmprss2tm3Sho mutation (0 available); any Tmprss2 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:212219 )
• regions of invasive prostate adenocarcinoma in mice over 1 year of age

mortality/aging
mortality/aging ( J:212219 )
N
• mice survive at least 1 year

neoplasm
increased prostate gland adenocarcinoma incidence ( J:212219 )
• regions of invasive prostate adenocarcinoma in mice over 1 year of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:212219 )
• regions of invasive prostate adenocarcinoma in mice over 1 year of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory