Phenotypes Associated with This Genotype

Genotype
MGI:5576760

• Allelic Composition: Per2^tm1Drw/Per2^tm1Drw
• Genetic Background: B6.129-Per2^tm1Drw/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:208598 )

• mice show a 25% reduction in the number of vessels in the sciatic nerve indicating that the network of vasa nervorum is reduced

abnormal retina vasculature morphology ( J:208598 )

• 40% increase in acellular capillaries in the retina indicating retinal vascular damage

hematopoietic system

abnormal bone marrow cell morphology/development ( J:208598 )

• mice exhibit bone marrow neuropathy, with a decrease in tyrosine hydroxylase-positive and neurofilament 200-positive nerve processes at 4 and 12 months of age

increased hematopoietic stem cell number ( J:208598 )

• 4 month old mice show a 2-fold increase in lin- sca1+ c-Kit+ (LSK) cells within the bone marrow, indicating a dysfunction in bone marrow progenitor cell (BMPC) release from bone marrow

abnormal hematopoietic stem cell physiology ( J:208598 )

• BMPCs show decreased colony formation and NO levels

decreased hematopoietic stem cell proliferation ( J:208598 )

• BMPCs show a 3-fold decrease in proliferation

cellular

decreased hematopoietic stem cell proliferation ( J:208598 )

• BMPCs show a 3-fold decrease in proliferation

homeostasis/metabolism

improved glucose tolerance ( J:208598 )

• mice are normoglycemic and show better recovery after glucose challenge than wild-type mice

nervous system

abnormal nervous system morphology ( J:208598 )

• mice exhibit bone marrow neuropathy, with a decrease in tyrosine hydroxylase-positive and neurofilament 200-positive nerve processes at 4 and 12 months of age, respectively

vision/eye

abnormal retina morphology ( J:208598 )

• increase in retinal permeability

• dissociation of tight junctions and adherens junctional integrity in the retina

abnormal retina vasculature morphology ( J:208598 )

• 40% increase in acellular capillaries in the retina indicating retinal vascular damage