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Phenotypes Associated with This Genotype
Genotype
MGI:5576252
Allelic
Composition		 Il10tm1Cgn/Il10tm1Cgn
Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (43 available)
Nfil3tm1Pbro mutation (0 available); any Nfil3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
colitis ( J:209365 )
• mutants develop severe colitis with 100% penetrance at 5 weeks of age
increased interleukin-12 secretion ( J:209365 )
• IL-12b (IL-12p40) production from activated macrophages is increased compared to single mutants

digestive/alimentary system
diarrhea ( J:209365 )
• all mutants develop severe diarrhea
decreased colon length ( J:209365 )
• colon length is shorter
rectal prolapse ( J:209365 )
• 50% of mutants develop rectal prolapse by 5 weeks of age
colitis ( J:209365 )
• mutants develop severe colitis with 100% penetrance at 5 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory