Phenotypes Associated with This Genotype

Genotype
MGI:5575774

• Allelic Composition: Tardbp^m1H/Tardbp⁺; Tg(SOD1*G93A)^dl1Gur/0
• Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:211620 )

• as in Tg(SOD1*G93A)1Gur mice

muscle

decreased extensor digitorum longus weight ( J:211620 )

• compared with Tg(SOD1*G93A)1Gur mice

impaired muscle relaxation ( J:211620 )

• in the tibialis anterior compared with Tg(SOD1*G93A)1Gur mice

• however, relaxation time in the extensor digitorum longus is normal

abnormal muscle tone ( J:211620 )

• soft abdominal body tone as in Tardbp^m1H heterozygotes

behavior/neurological

decreased grip strength ( J:211620 )

• as in Tg(SOD1*G93A)1Gur mice

growth/size/body

decreased body weight ( J:211620 )

• as in Tg(SOD1*G93A)1Gur mice

nervous system

nervous system phenotype ( J:211620 )

N • mice exhibit normal numbers of motor neurons in the sciatic motor pool

limbs/digits/tail

decreased extensor digitorum longus weight ( J:211620 )

• compared with Tg(SOD1*G93A)1Gur mice