Phenotypes Associated with This Genotype

Genotype
MGI:5575664

• Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai; Tet2^tm1.1Iaai/Tet2^tm1.1Iaai; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:208092 )

• 40% of mice treated with polyinosinicpolycytidylic acid (pI:pC) at 4 weeks of life die by 50 weeks of age

hematopoietic system

abnormal myelopoiesis ( J:208092 )

• transplantation of bone marrow from mutants into lethally irradiated CD45.1 recipient mice that were treated with pI:pC results in a myelodysplastic syndrome and mice exhibit lower white blood cell counts and hematocrit, presence of dysplastic erythroid precursors, dysplastic myloid cells, and increased extramedullary hematopoiesis

immune system

abnormal myelopoiesis ( J:208092 )

• transplantation of bone marrow from mutants into lethally irradiated CD45.1 recipient mice that were treated with pI:pC results in a myelodysplastic syndrome and mice exhibit lower white blood cell counts and hematocrit, presence of dysplastic erythroid precursors, dysplastic myloid cells, and increased extramedullary hematopoiesis