Phenotypes Associated with This Genotype

Genotype
MGI:5574307

• Allelic Composition: Bcl3^tm1Sbn/Bcl3^tm1Sbn
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased transitional stage T1 B cell number ( J:207111 )

decreased transitional stage T2 B cell number ( J:207111 )

decreased follicular B cell number ( J:207111 )

increased marginal zone B cell number ( J:207111 )

• intrinsic to B cells and cell autonomous

abnormal B cell physiology ( J:207111 )

• in cocultures, splenic B cells result in better proliferation of CD4+ T cells compared with wild-type cells

decreased B cell proliferation ( J:207111 )

• of alphaIgM-stimulated follicular B cells

increased B cell proliferation ( J:207111 )

• of LPS-stimulated marginal zone and follicular B cells

hematopoietic system

decreased transitional stage T1 B cell number ( J:207111 )

decreased transitional stage T2 B cell number ( J:207111 )

decreased follicular B cell number ( J:207111 )

increased marginal zone B cell number ( J:207111 )

• intrinsic to B cells and cell autonomous

abnormal B cell physiology ( J:207111 )

• in cocultures, splenic B cells result in better proliferation of CD4+ T cells compared with wild-type cells

decreased B cell proliferation ( J:207111 )

• of alphaIgM-stimulated follicular B cells

increased B cell proliferation ( J:207111 )

• of LPS-stimulated marginal zone and follicular B cells

cellular

decreased B cell proliferation ( J:207111 )

• of alphaIgM-stimulated follicular B cells

increased B cell proliferation ( J:207111 )

• of LPS-stimulated marginal zone and follicular B cells