Phenotypes Associated with This Genotype

Genotype
MGI:5574110

• Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:163663 )

• 50%-60% die sometime between 1 and 6 months of age

vision/eye

cornea vascularization ( J:163663 )

• vascularized and proliferative corneal lesion developed in the central region of the cornea

increased incidence of corneal inflammation ( J:163663 )

• neutrophils and macrophages

abnormal cornea epithelium morphology ( J:163663 )

• occasional dying keratinocytes are present

increased cornea epithelium thickness ( J:163663 )

• severe corneal epithelial thickening is observed, occurring abruptly at the junction of the central and peripheral

decreased cornea thickness ( J:163663 )

• at 25 days, the corneal epithelium is slightly thinner and keratinocytes are less orderly

liver/biliary system

liver inflammation ( J:163663 )

• slowly progressive hepatic inflammation

• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils

liver fibrosis ( J:163663 )

• capsular fibrosis and inflammation is also seen

cardiovascular system

cornea vascularization ( J:163663 )

• vascularized and proliferative corneal lesion developed in the central region of the cornea

immune system

increased incidence of corneal inflammation ( J:163663 )

• neutrophils and macrophages

liver inflammation ( J:163663 )

• slowly progressive hepatic inflammation

• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils