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Phenotypes Associated with This Genotype
Genotype
MGI:5573199
Allelic
Composition
Tg(Thy1-Snca)1S13Putt/0
Uchl1tm1Dgen/Uchl1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-Snca)1S13Putt mutation (0 available)
Uchl1tm1Dgen mutation (1 available); any Uchl1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 3.5 months of age, mutants need to be sacrificed due to poor health

nervous system
• mice show a large increase in astrogliosis at 3.5 months of age compared to single Tg(Thy1-Snca)1S13Putt mutants, especially in the cortex and to a lesser extent in the hippocampus and the striatum, but not in the cerebellum, brainstem, and thalamus
• 3.5 month old mice however, do not show microgliosis or axon degeneration
• increase in perikaryal alpha-synuclein accumulation in the cell soma of hippocampal neurons at 3.5 months of age

behavior/neurological
• mice show greater deficits in motor coordination on the rotarod than single Uchl1 homozygotes at 2.5 months of age
• mice show greater deficits in muscle strength than single Uchl1 homozygotes at 2.5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:607688
OMIM:610297
OMIM:613643
OMIM:614251
OMIM:PS168600
J:207278


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory