Phenotypes Associated with This Genotype

Genotype
MGI:5573130

• Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:210950 )

• no mice treated with TNF die unlike all wild-type mice

immune system

decreased circulating interleukin-6 level ( J:210950 )

• decreased induction in TNF-treated mice

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:210950 )

• decreased induction in TNF-treated mice

abnormal response/metabolism to endogenous compounds ( J:210950 )

• TNF-treated mice fail to exhibit lethality, as great IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice