Phenotypes Associated with This Genotype

Genotype
MGI:5572798

• Allelic Composition: Tshr^hyt-3J/Tshr^hyt-3J
• Genetic Background: CXB10/HiAJ-Tshr^hyt-3J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

proportional dwarf ( J:210510 )

• homozygotes are approximately half the normal size

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:210510 )

• Two of two homozygotes assessed at four and a half weeks of age showed elevated thresholds at all frequencies whereas wildtype controls had elevated frequencies only at 32 kHz

reproductive system

reduced female fertility ( J:210510 )

♀ • compared with controls homozygous females have reduced fertility, but many do breed without hormone supplements when crossed to BALB/cByJ males

reduced male fertility ( J:210510 )

♂ • only one male homozygote bred on this CXB10/HiAJ background, but when bred further to BALB/cByJ male homozygous fertility improves

endocrine/exocrine glands

decreased activity of thyroid gland ( J:210510 )

mortality/aging

lethality at weaning, incomplete penetrance ( J:210510 )

• many homozygotes die around 3 weeks of age, and if they survive through wean age will usually survive to adulthood and live a relatively normal lifespan

premature death ( J:210510 )

• there is some premature death in the adult population

prenatal lethality, incomplete penetrance ( J:210510 )

• heterozygous intercrosses produce fewer than the expected 25% homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital hypothyroidism		DOID:0050328	OMIM:PS275200	J:210510