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Phenotypes Associated with This Genotype
Genotype
MGI:5572798
Allelic
Composition
Tshrhyt-3J/Tshrhyt-3J
Genetic
Background
CXB10/HiAJ-Tshrhyt-3J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tshrhyt-3J mutation (1 available); any Tshr mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• homozygotes are approximately half the normal size

hearing/vestibular/ear
• Two of two homozygotes assessed at four and a half weeks of age showed elevated thresholds at all frequencies whereas wildtype controls had elevated frequencies only at 32 kHz

reproductive system
• compared with controls homozygous females have reduced fertility, but many do breed without hormone supplements when crossed to BALB/cByJ males
• only one male homozygote bred on this CXB10/HiAJ background, but when bred further to BALB/cByJ male homozygous fertility improves

endocrine/exocrine glands

mortality/aging
• many homozygotes die around 3 weeks of age, and if they survive through wean age will usually survive to adulthood and live a relatively normal lifespan
• there is some premature death in the adult population
• heterozygous intercrosses produce fewer than the expected 25% homozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital hypothyroidism DOID:0050328 OMIM:PS275200
J:210510


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory