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Phenotypes Associated with This Genotype
Genotype
MGI:5571719
Allelic
Composition		 Artm2.1Reb/Ar+
Tg(Amh-cre)8815Reb/?
Genetic
Background		 129S(FVB)-Artm2.1Reb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm2.1Reb mutation (2 available); any Ar mutation (23 available)
Tg(Amh-cre)8815Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal Sertoli cell barrier morphology ( J:210656 )
• seminiferous tubules have stretches of severely disorganized Sertoli cell tight junctions interspersed with intact areas
• preleptotene spermatocytes are enclosed in incomplete Sertoli cell tight junction compartments
abnormal Sertoli cell barrier function ( J:210656 )
• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

reproductive system
abnormal Sertoli cell barrier morphology ( J:210656 )
• seminiferous tubules have stretches of severely disorganized Sertoli cell tight junctions interspersed with intact areas
• preleptotene spermatocytes are enclosed in incomplete Sertoli cell tight junction compartments
abnormal Sertoli cell barrier function ( J:210656 )
• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory