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Phenotypes Associated with This Genotype
Genotype
MGI:5571470
Allelic
Composition		 Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation (0 available); any Adam17 mutation (62 available)
Tg(Scgb1a1-rtTA)2Jaw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (7 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:210193 )
N
• doxycycline-treated mice exhibit normal neonatal survival

respiratory system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice
abnormal lung saccule morphology ( J:210193 )
• doxycycline-treated mice exhibit enlarged airspaces with fewer number of saccules and reduced epithelial cell differentiation compared with control mice

cellular
decreased cell proliferation ( J:210193 )
• in the lungs of doxycycline-treated mice

cardiovascular system
abnormal lung vasculature morphology ( J:210193 )
• reduced pulmonary capillary formation in doxycycline-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory