Phenotypes Associated with This Genotype

Genotype
MGI:5571383

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺; Hk2^tm1.1Uku/Hk2^tm1.1Uku; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:210113 )

• median survival is 31 days compared with mice with wild-type Hk2 that die by P20

neoplasm

abnormal tumor vascularization ( J:210113 )

• increased micro-vascularization

decreased tumor growth/size ( J:210113 )

• compared to in mice with wild-type Hk2

increased medulloblastoma incidence ( J:210113 )

• all mice develop tumors with reduced growth and at increased latency compared to in mice with wild-type Hk2

increased tumor latency ( J:210113 )

• all mice develop tumors with increased latency compared to in mice with wild-type Hk2

nervous system

abnormal neuronal precursor proliferation ( J:210113 )

• reduced cerebellar granule neuron progenitors proliferation

increased medulloblastoma incidence ( J:210113 )

• all mice develop tumors with reduced growth and at increased latency compared to in mice with wild-type Hk2

cellular

abnormal neuronal precursor proliferation ( J:210113 )

• reduced cerebellar granule neuron progenitors proliferation

cardiovascular system

abnormal tumor vascularization ( J:210113 )

• increased micro-vascularization