Phenotypes Associated with This Genotype

Genotype
MGI:5571296

• Allelic Composition: Bcl11b^tm2.1Jpk/Bcl11b⁺; Tg(Lck-cre)1Jtak/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell number ( J:210122 )

• increased percentage of immature single positive cells in irradiated mice

decreased thymocyte number ( J:210122 )

• in irradiated mice

increased double-negative T cell number ( J:210122 )

• increased percentage in irradiated mice

decreased double-positive T cell number ( J:210122 )

• decreased percent in irradiated mice

decreased CD4-positive, alpha-beta T cell number ( J:210122 )

• decreased percent in irradiated mice

decreased CD8-positive, alpha-beta T cell number ( J:210122 )

• decreased percent in irradiated mice

neoplasm

increased lymphoma incidence ( J:210122 )

• thymic lymphomas in 4 of 5 irradiated mice

cellular

abnormal cell cycle ( J:210122 )

• attenuated radiation-induced cell cycle arrest at the S phase in immature single positive cells of irradiated mice

endocrine/exocrine glands

decreased thymocyte number ( J:210122 )

• in irradiated mice

hematopoietic system

abnormal T cell number ( J:210122 )

• increased percentage of immature single positive cells in irradiated mice

decreased thymocyte number ( J:210122 )

• in irradiated mice

increased double-negative T cell number ( J:210122 )

• increased percentage in irradiated mice

decreased double-positive T cell number ( J:210122 )

• decreased percent in irradiated mice

decreased CD4-positive, alpha-beta T cell number ( J:210122 )

• decreased percent in irradiated mice

decreased CD8-positive, alpha-beta T cell number ( J:210122 )

• decreased percent in irradiated mice